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Welcome to the new ATCC blog!

Welcome to the new ATCC blog! We have created this forum to provide a fun and educational way for Microbiologists and Cell Biologists to learn more about the natural world and to stay connected with new and exciting topics, techniques, and best practices in science.

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The ideal characteristics of an in vitro whole-cell model include equivalence to in vivo physiology, genotypic and karyotypic stability, high proliferative capability, and the ability to be used at high passage. Does such a cell type exist? In this blog entry, I will discuss human telomerase (hTERT)-immortalized cells (ICs), which possess all of these qualities.

The basics of cryopreservation

By Carol Horton

Preservation becomes essential in the routine maintenance of cultures, allowing us to minimize passage in vitro and preserving valuable stocks used or developed in research. The most common methods of preservation include cryopreservation, which is the process of freezing cultures, and lyophilization, which is the process of freeze-drying material for longer-term storage and stability. Central to both techniques is the management of water during the preservation process. Here, we will discuss the basics of cryopreservation.

The Rise of Cell Authentication

By Maryellen de Mars

The issue of misidentified cell lines is nothing new to the scientific community, but recent attention toward addressing this persistent challenge seems to have increased. However, there has been considerable advances in rectifying the problem of irreproducibility in science and promoting the need for standards in addressing this issue.

Welcome to the new ATCC blog!

By Cara Wilder

Welcome to the new ATCC blog! We have created this forum to provide a fun and educational way for Microbiologists and Cell Biologists to learn more about the natural world and to stay connected with new and exciting topics, techniques, and best practices in science.

Primary cells; in vitro models of physiological relevance

By Brian Shapiro

Human primary cells (HPCs) are frequently disregarded as a choice for cell cultures as they typically require more technical expertise to establish in the laboratory. While HPCs may be challenging to generate, they have much in common with cells in vivo; they retain many of the secretory, barrier, contractile, and other physiological functions of their in vivo condition. When acquired from a respected biological resource center, HPC maintenance is similar to that of any other cell line, thanks to the availability of optimized media and reagent formulations, affordable cell matrix solutions, and detailed protocols.

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